Hiển thị các bài đăng có nhãn Lavender. Hiển thị tất cả bài đăng
Hiển thị các bài đăng có nhãn Lavender. Hiển thị tất cả bài đăng

Thứ Hai, 18 tháng 1, 2016

The Wondrous Essential Oils: Lavender and our Nervous System (Part 3)

Pain and Lavender:

Lavender oil has been reported to be useful in treating acute pain as well as in chronic and/or intractable pain. It has been shown in 100 patients using Lavender essential oil for foot massage that 50% were receiving artificial ventilation, and was effective in reducing blood pressure, heart rate, breathing rate, wakefulness, and overall pain.

In the treatment of recurrent Aphthous ulcer, using Lavender oil has revealed a significant pain relief in the majority of the 115 patients, and only in the first dose. This resulted in the reduction of the ulcer size, the increased frequency of mucosal repair, and healing within three days of treatment; compared to baseline and placebo groups.

The use of Lavender produced that the stress level, the Bispectral index (a promising sedation monitoring parameter), and the intensity of the pain of needle insertion were significantly reduced after receiving oxygen with a mask covered with Lavender oil. This experiment lasted for five minutes, compared with the control in thirty volunteers. The aromatic oil massage using essential oils mixed with Lavender, sage, marjoram on a 2: 1: 1, in forty-eight outpatients with primary dysmenorrhea, reduced pain, and reduced the duration of dysmenorrhea.

Aromatherapy with Lavender oil, also reportedly worked as a successful and safe adjunctive therapy in reducing pain after caesarean section in 200 pregnant women, and after episiotomy (vaginal surgery) in 60 primiparas (first birth), and in perineal discomfort (reproductive organ system component) after normal delivery, in 635 women.




It has been shown that Lavender aromatherapy through an oxygen mask with two drops of lavender oil at 2% can be used as an analgesic to reduce demand for opiates, in twenty-five patients postoperatively, and immediately after surgery and biopsy. In contrast to these observations, the scent of Lavender essential oil facilitates anxiety but no pain perception, during cosmetic facial injections of botulinum toxin for the correction of the frown lines.

In an eight-session course manual of acupressure with Lavender oil (lavender oil 3%, which is used as a lubricant massage) for a period of three weeks in patients with neck pain subacute nonspecific (32 patients) or pain lumbar (61 patients), significantly relieved their neck and back pain and improved movement of the cervical and lumbar spine. The inhalation of Lavender essential oil is suggested and is a safe treatment against acute migraine pain.

A report dicussed how forty-seven patients suffering from migraine attacks experienced a significant reduction in pain intensity and associated symptoms, fifteen minutes after inhaling Lavender oil (2-3 drops of essential oil of lavender rubbed on his upper lip) in the early stages of the attacks. In aromatherapy, massages accompanied with Lavender geranium, rose, jasmine, almond oils spring, once a week for eight weeks, was reported as an effective treatment for the symptoms of menopause hot flashes, depression and pain, and in climacteric women.

The Cognition process and Lavender:

Using scents to affect one’s mood has been reported by several ancient doctors as well as in Medieval Times, just as the positive effects of various medicinal plants as cognitive enhancers has been reported, as well. To assess the olfactory impact of essential oils of Lavender on cognitive performance and mood in healthy volunteers, it was used the Computerized Cognitive Assessment Battery in the research conducted on 144.



Performance analysis revealed that the smell of Lavender (four drops of oil were applied to a pad diffusor) produced a significant decrease in performance of the 'main memory', and reaction times in disabilities, as well as for memory and attention.

Additionally, significant effects were found in Lavender, compared with other control groups, indicating that Lavender is able to raise the mood, or at least maintain a good mood while performing battery challenge tests in laboratory conditions. It was found to improve the emotional states in the work environment as a result of using Lavender oil burners.

The use of Lavender oil burners for a period of three months has shown that almost 90% of respondents (a total of 66 subjects), were believed to cause an improvement in the working environment due to the use of Lavender oil. In the use of aromatherapy, using essential oils such as rosemary and lemon in the morning, and Lavender and orange at night showed significant improvement in personal guidance related to cognitive function in 28 elderly patients that were suffering from various forms of dementia.

It has been shown that the unconscious perception of the smell of Lavender can significantly affect the rate of errors in tests of mathematical counting and letters. In the presence of the smell of Lavender in 108 subjects, individuals made ​​fewer mistakes than in the presence of any odor or smell of jasmine. In comparison, it has been reported that the use of Lavender might deteriorate arithmetic reasoning, but not memory, compared to clove oil, and with no concomitant effect on mood. The oral application of lavender (80 mg / day) for six weeks, in fifty patients suffering from neurasthenia disorder or PTSD, showed significant improvements in their state of general mental health and their quality of life.

Precautions in using Lavender:



Although there is insufficient evidence to recommend Lavender for short-term treatment in some neurological disorders, long-term trials and observational studies have been establishing the safety of long-term and overall effectiveness, in the context of treatment and control, and are need to mitigate these diseases.

Available data suggests that short-term therapy with the Lavender is relatively safe. However, there are some reports of adverse effects after the application of Lavender. Its use in gynecomastia (excessive development of Mammal glands in men) coincided with the topical application of products containing tea tree oils and Lavender. This was reported after use in three children between 7 and 10 years of age. In addition, studies in human cell lines indicated that Lavender oil had estrogenic and anti-androgenic activities.

Lavender should also be used with caution or avoided in patients with known allergies in relation to Lavender. In trials of Lavender in oral use, it was reported few adverse events in the group were related to Lavender than the placebo group, the most common adverse effects were related to infections and infestations, followed by gastrointestinal disorders and nervous system disorders. The physicians Schlafke Woelk reported a higher adverse events in the Lavender groups rather than the group related to Lorazepam, but were not described as serious. Gastrointestinal adverse events like nausea and dyspepsia, after receiving Silexan, were reported. Ingestion should be avoided during pregnancy and lactation. Lavender oil has no potential for drug abuse.




Endnotes about Lavender:

A recent increase in the popularity of alternative medicine and natural products has renewed the interest in Lavender and essential oils, as a possible natural remedy. This view may be useful to increase our knowledge of the Lavender in the pharmacological effects, and improve our future plans for clinical and experimental research.



There is evidence that Lavender can have significant clinical potential either by itself or as adjunctive therapy in the different disorder. However, due to some problems such as the methodological shortcomings; small sample sizes, short duration of application of Lavender, the lack of information regarding the portion of the dose variation between trials efficiency and effectiveness, the variability of the methods of administration, the absence of a comparator placebo, or the lack of control groups; is necessary research experiments and more standard rhythms, to confirm the beneficial effect of Lavender in neurological disorders.

Methodological problems identifying some oils, has also hampered the assessment of therapeutic importance the Lavender research. Dried lavender flowers used in some trials were obtained from a local herbal store, and although taxonomic identification was confirmed in these studies, no quantification of the key components of the herbal product quality, may be questionable.



Although some studies defining the content of Lavender is excellent, it is essential that all future clinical studies specify the exact derivation of the oils used in the study, and preferably include a profile of the liquid or the percentage composition of the main constituents. In addition, several factors such as temperature; skin type, quality and size of the treatment area, which can affect the level and rate of absorption of Lavender after massage or aromatherapy; were not considered in several investigations.

Many discrete compounds in Lavender oil have shown a large number of potential therapeutic effects, and researchers continue to search for new treatments for various diseases.

Only few clinical research on Lavender are available using different methods of administration (eg, orally, in aromatherapy, and as a massage oil). Evidence of the oral Lavender is promising; however, until independent studies with follow-up data appear in a long-term studies, will not be conclusive. The administration and uses of Lavender (aromatherapy, inhalation, massage, etc.) is not currently supported with good evidence of its effectiveness yet.

Future clinical trials, well informed and adopting a standard and rigorous methodology, in combination with the experimental pharmacological research, would help to clarify the therapeutic value of the Lavender in neurological and psychological disorders.

The apparently low reporting of adverse reactions could involve safety and tolerability. However, most studies did not provide details that may have been masked, and the studies involved only had a small number of individuals. This is crucial for safety and tolerability data on all modes of Lavender application. Thus the longer term follow-up would be required, especially for oral Lavender in neurological and / or psychological treatment.

However, the tremendous benefit of Lavender in our daily life cannot be denied and both oral and olfactory aromatherapy uses has been demonstrated. Only further research could open the scientific door for using Lavender in the medical field.

Sources:
Peter Hossein Koulivand, Maryam Khaleghi Ghadiri and Ali Gorji.
Shefa Neuroscience Research Center, Tehran 1996835911, Iran
Klinik und für Neurochirurgie Poliklinik Germany, Universitätsklinikum Münster, 48149 Münster,
Neuroscience Research Center Razavi, Mashhad 9198613636 Iran
Research Center epilepsy, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany
Institut für Physiology I, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany
Department of Neurology, 48149 Münster, Germany

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Thứ Năm, 14 tháng 1, 2016

Wondrous Essential Oils: Lavender and the Nervous System (Part 2)

Human studies:

Although there is considerable debate over whether the different species of lavender have significant clinical potential, either alone as additives to other substances, many human studies support its effectiveness in different neurological and psychological disorders. Lavender is mainly used through oral administration, aromatherapy or massage, and in several clinical studies many benefits were attributed to its use in this way.

In addition to psychological effects, aromatherapy is believed to be therapeutically effective due to the physiological effects of inhaled volatiles. It is believed that when inhaled, the limbic system - a system consisting of several brain structures that manage physiological responses to emotional stimuli. It is related to memory, attention, sexual instincts, emotions for example pleasure, fear, aggressiveness, personalities and behavior. The limbic system consists of parts of the thalamus, hypothalamus, hippocampus, amygdala, corpus callosum, septum and brain-, particularly the amygdala and hippocampus, the linalool and linalyl acetate (which is a vast, different kind of organic derived compounds) are rapidly absorbed through the skin after topical application to massage, and are believed to be capable of causing depression in the central nervous system.

Lavender in Anxiety and Depression:

Lavender is used in the treatment of anxiety and related disorders. In three clinical trials, recently investigated, were identified the effectiveness of the administration of Lavender oil orally when taken once a day and at a dose of 80 mg / day, in anxiety disorders and generalized anxiety disorders as well as anxiety and agitation. The anxiolytic effect of Lavender exceeded a placebo group, administered to 221 patients suffering from anxiety disorder. In addition, the Lavender improved symptoms associated with the restlessness, sleep disorders, and somatic complaints, also had a beneficial influence on the welfare and quality of life in general.



According to this study, during 6-week, after oral intake of Lavender oil compared with lorazepam, was found efficacy in generalized anxiety disorder in adults, this Lavender study indicated that effectively reduces generalized anxiety.

In the study it reported relief of anxiety and mood improved in thirty-six patients admitted to an intensive care unit and receiving Lavender oil (diluted at a concentration of 1%) in the form of aromatherapy.

The same results were presented for fourteen female patients who were being treated with chronic hemodialysis (it is a process of purifying the blood in people that their kidneys are not working normally). In a survey conducted on a long stay in the outpatient department of Neurology, showed an increase in the results of mood and psychological distress after application of aromatherapy with Lavender, and was accompanied by the oil of 'Tea tree ' and 'Rosemary '.

An investigation about the effects of Lavender in aromatherapy (diluted in a concentration of 2%), on cases of anxiety and depression in postpartum women at high risk, showed significant improvement. This study was conducted using the scale Postnatal Depression and Generalized Anxiety Disorders, after four consecutive weeks of administration of the Lavender. The smell of lavender reduces anxiety in dental patients; however, it has no effect on anxiety thoughts surrounding future dental visits.



In the test of 'visual analog scales' to assess anxiety, it shown that Lavender has low risk during a simple cost-effective intervention for the purpose of potentially improves preoperative anxiety. Lavender capsules orally administered containing 100 or 200 ul of organic Lavandula Aangustifolia oil, were tested on responses to movie clips that cause anxiety. In this study, shown by the scale, the assessment of mood either positively or negatively affected the heart rate. The galvanic response, suggested that Lavender has anxiolytic effects in humans suffering from low anxiety, but these effects can not extend to the conditions of severe anxiety.

A clinical research indicated an antidepressant effect of Lavender. Adjuvant therapy infusion of Lavender, and imipramine (which is a chemical group belonging to antidepressant drug, whose use is in clinical cases of major depression, and its use is evaluated in cases of disorder and / or panic attacks ) used in the treatment of forty-eight adult outpatients suffering from mild to moderate depression, it led to a high improvement. Side effects such as dry mouth and urinary retention were observed less frequently when administered with Lavender Imipramine. These results suggest that Lavender is an effective adjuvant therapy in combination with imipramine, resulting in a superior and more rapid improvement in depressive symptoms.

Neuroimaging and Lavender:


An evaluation of regional cerebral metabolic activity, with positron emission tomography, in ten healthy women after stimulation to the smell of Lavender showed improvement in the orbitofrontal neuron, the posterior cingulate gyrus, brainstem, thalamus, and the cerebellum. These findings suggest that Lavender in aromatherapy, plus relaxation effect may increase the level of excitement in some subjects.

Using Functional Magnetic Resonance Imaging (FMRI) a significant activation was shown in the main olfactory brain structures, including the olfactory primary cortex, the entorhinal cortex, the hippocampus, cortex, hippocampus, thalamus, hypothalamus, orbitofrontal cortex and insular cortex, and the extension of the lateral inferior frontal region. This study, reported, was conducted in nineteen healthy participants after application of 10% diluted in Lavender Dipropylene (which it is an organic alcohol compound, a colorless, tasteless and odorless. It is a clear oily liquid used as a solvent).

After sensory stimulation with Lavender, increased of the cortical perfusion was observed. This was assessed by computed tomography photon emission in ten healthy adults. Significant activation was observed in the gyrus rectus, the orbitofrontal cortex and superior temporal cortical areas. A slight increase in perfusion was also average temporal and parietal-occipital regions. The smell of Lavender was made ​​through orthonasal (odor perceived through the nose) and aftertaste (odor perceived by mouth), the routes and the response of the brain were measured with fMRI in 20 subjects.



Besides activation on the basis of the central sulcus, by Lavender, retro nasal smell stimulation resulted in a 'spike' in the ventral insula significant compared to orthonasal application. In contrast, orthonasal application was a 'spike' in the right caudal nucleus of the brain, which came in importance compared to the retro nasal way.

The electroencephalogram (EEG) and Lavender:

It has been suggested that some neurological disorders, shown significantly through the EEG, such as epilepsy, can be benefited by using aromatherapy. Lavender affects human pattern (EEG) with his anxiolytic effect. It has been reported that inhalation of Lavender (diluted in a 10% concentration) for 3 minutes increases power curve alpha EEG and reduces anxiety and improved mood, these were observed in 40 healthy adults.

The increases in activity of the theta (4-8 Hz) and alpha (8-13 Hz) may display a variety of general relaxation effects and can be induced by chemical and non-chemical techniques. It has been shown that during inhalation of Lavender (diluted in a 10% concentration) in 20 participants, the potency of activities theta and alpha was significantly increased in all brain regions. This study found relaxing effects increments of alpha wave activity after administration of Lavender; this is indicated in EEG tests relaxation and was produced by using aromatherapy.

Moreover, aromatherapy using Lavender was reported to produce EEG patterns with features in the subjects, of 'feel comfortable“. Lavender oil administered in a stream of aroma, it showed modest efficacy in the treatment of agitated behavior in patients with severe dementia.



As for the front asymmetry shown by EEG, suggested be a predictor of change in symptoms, functioning effectively in patients with social anxiety disorders in their final state, and undergoing psychological treatment. Assessing the frontal EEG asymmetry performed in thirty-nine adult participants and Twenty-seven newborns, revealed ended on greater activation in the left frontal EEG (associated with increased behavioral approach and affecting less depressed) after use of aromatherapy with Lavender.

Other studies in these volunteers indicated that Lavender can induce in the left frontal EEG changes in adults and children who show higher baseline on the right frontal EEG activation. It is suggested that children and adults with greater activation of the right frontal EEG compared to baseline, may be more affected by the application of the Lavender.

Sleep and Lavender:

Lavender has been recommended as an excellent natural remedy to treat insomnia and improve sleep quality. Randomized studies, which were investigated, showed the effectiveness of the smell of lavender in the quality of sleep, and showed that the mean scores improved sleep quality in fifteen and sixty-four patients with ischemic heart disease (which is a generic designation for a group of closely related disorders, where there is an imbalance between oxygen supply and demand substrates heart) and in thirty-four middle-aged women with insomnia. The ten people with insomnia, verified by a score of 5 or more in the index Pittsburgh Sleep Quality (ICSP), were treated with the smell of Lavender. They received six to eight drops of Lavender oil added every night in the cartridge, showing improving to -2.5 score points ICSP.



Most notable improvements were observed in women and younger participants, and insomnia also improved more in most serious cases. The oil dressing oral Lavender (mixed) - 80 mg / day - showed a beneficial and significant influence on the quality and duration of sleep, and the improvement of mental and physical health in general. This study was applied on 221 patients suffering from disorder of syndrome of anxiety, without causing any unwanted sedative or other specific effects of drugs. A blend of essential oils like Lavender, basil, juniper, and marjoram, shown to reduce sleep disturbances, and improve the general welfare in older patients.

In a clinical study in four geriatric patients dependent on benzodiazepines (which are psychotropic drugs that act on the central nervous system with, sedative, hypnotic, anxiolytic, anticonvulsant, amnestic and muscle relaxant effects) a significant decrease in sleep duration it was found by discontinuation of benzodiazepines, which was restored to previous levels by replacing aromatherapy with Lavender oil. This study suggests that environmental Lavender oil can be used as a temporary relief of continuous medication for insomnia and reduces the side effects of these drugs.



In a study in thirty-one hospitalized patients, the administration of Lavender oil showed a trend towards a better quality of wakefulness during the day and more sustained sleep at night. Contrary to these data, it should be noted that the use of aromatherapy with Lavender oil has no beneficial effect on sleep patterns in children with autism, assisting a residential school. It was suggested that this therapy may show greater effects on the home environment or long-term interventions.

Part 2 of 3

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Thứ Tư, 13 tháng 1, 2016

The Wondrous Essential Oils: Lavender and our Nervous System (Part 1)

In a previous article, we dove in and explained the excellent properties of essential oils and the role that they play in our daily lives. Now in this article, we want to specifically talk about a plant called Lavender. The essential oil extracted from this plant, is traditionally known for having a variety of therapeutic and healing properties ranging from inducing relaxation to the treatment of parasitic infections, burns, insect bites, and muscle spasms.

There has currently been growing evidence to suggest that Lavender oil may be an effective drug in the treatment of several neurological disorders. Several studies conducted in humans and animals in which Lavender was used suggested that it helps remediate properties such as anxiolytic, mood stabilization, sedative, analgesic and anticonvulsant, and neuro-protectiveness. These studies raised the possibility of the resurgence of Lavender in the therapeutic efficacy of neurological disorders. In this article, we have offered an explanation of the current experimental and clinical effects of Lavender in our nervous system.

What is the Lavender Plant?

This plant comes from the Lavandula genus, which is native to the lands surrounding the Mediterranean Sea, Southern Europe, Eastern Europe, North Africa, Middle East, South Asia, and Southeast India. There are currently more than 30 species and hundreds of subspecies, hybrids, and selective crops.

Different forms of this plant vary in size and can range from 9 inches to 3 feet, although some plants may grow according to their age. Ultimately, Lavender is divided into four main categories: Lavender Agustifolia, commonly known as English Lavender; Stoechas Lavender, a large plant of foliage greenish gray color, and late flowering with a very strong odor (sometimes known as French Lavender); Latifolia Lavender, which is similar to a Mediterranean grass; and Lintermedia Lavender which is a sterile cross between Lavender and Lavender Latifolia Angustina.



Different forms of Lavender plants have similar ethnobotanical properties and its main chemical components consist of the following: linalool, linalyl acetate, cineol terpinen, and camphor (the ethnobotanical studies the relationships between human groups and their vegetable environment in the use and development of plants in different cultural spaces and time) however, the relative level of each component differs according to the type of species. Lavender oil can be procured from the flowers of Lavandula Angustifolia (Family: Lamiaceae) through the process called steam distillation. The oil extracted through this process is mainly composed of the following chemicals: linalyl acetate, linalool, lavandulol acetate lavandulyl, and camphor.

The main components found in Lavender oil that are used during aromatherapy are linalool and linalyl acetate. The allocation of these two components is 51% (linalyl acetate) and 35% (linalool). This can be measured using a process called Gas Chromatography, and is linked to the use of gas properties. (Gas Chromatography is a set of techniques based on the principle of selective retention, which aims to separate the different components of a mixture, allowing identifying and determining the amounts of such components.)

The more proper use of Lavender is recommended via oral administration. However, it is also being used in aromatherapy, inhalation, massage, oil leakage, and bathrooms. Unlike many other essential oils used in aromatherapy, Lavender oil is often applied to the skin without being diluted. In a recent study, it was suggested that the essential oils and their components are quickly absorbed through the skin.



Even dating back to Medieval Times, Lavender has been a primary source in the preparation of drugs, perfumes, soaps, flavoring, and crafts. Lavender has a long history of medicinal use and it is suggested that this oil possesses an anticonvulsant, antidepressant, anxiolytic, sedative, and other soothing properties. Lavender was also prescribed by medieval doctors like Ebn-e-Sina and Razi, to treat seizures and migraines. Additionally, Lavender is considered beneficial in the treatment of pain and tremors.

In recent years, several researches have evaluated the medical and traditional remedies of Lavender, and have developed scientific methods to conduct numerous studies. These studies raised the possibility of reviving the therapeutic efficacy of Lavender in neurological disorders, and are mainly based on evidence of their medical efficacy.

Lavender in Animal Studies:

Several experiments using Lavender in animals, suggest an anxiolytic, sedative, analgesic and anticonvulsant and neuroprotective properties. It showed that Lavender has an anti-conflicting effect in mice. Continuous exposure to the essential oil of Lavender in rats, for 7 days, significantly inhibited anxiety and depression-like behavior as well as in the high tests of 'labyrinths', and in the forced swim test in these animals.



Lavender oil has been showing significant anxiolytic effects, in several tests used. Linalool, a major constituent of Lavender oil, produced significant effects on anti-conflicting cases, and also found that the effects were similar to those of Lavender oil. The effects of Lavender oil in rats, compared with the similar chemical called Chlordiazepoxide, achieved improvements in their behaviors in open field tests.

The effects of Lavender oil showed anti-anxiety properties, which were similar to those shown by the chemical component called Chlordiazepoxide. The anxiolytic effects of Lavender resonated with the effects of Diazepam when an elevated maze test was performed in the 'Mongolian Gerbil' animal (Diazepam is a derivative of Benzodiazepine, anxiolytic sedatives, muscle relaxants, anticonvulsants and drug), the smell of Lavender exposure showed an anxiolytic profile like diazepam in 'Gerbils females'. The investigation of the effects of inhaling linalool found that anxiety, aggression, and social interaction in mice enhanced anxiolytic properties during the test called 'dark without light ". Subsequently, there was increased social interaction, and decreased aggressive behavior.



The local anesthetic effect of lavender and its components (linalool and linalyl acetate) had a positive report in both "live" and in animal experiments in vitro. In a reflex test of Rabbit conjunctival, a treatment with a solution of Lavender essential oil, as well as linalool or linalyl acetate induced an improvement dose-dependency in the number of stimuli required to cause glare. The methanol extract of Lavender produced dose-dependency and sedative effects in mice.

To evaluate the sedative effects of lavender in the immobility of mice over-agitated induced by caffeine, it had to be determined after inhalation of Lavender. The smell of Lavender significantly increased the state of immobility in mice treated with caffeine. Exposure of mice to the smell of Lavender in a dark cage resulted in depression of motor activity, while plasma levels of linalool increased in proportion to the duration of exposure.

An intra-plantar injection of capsaicin produces an intense response and short 'licking/ biting' in mice (this chemical compound is an active component of chili peppers. Irritating to mammals and produces a strong burning sensation in the mouth) and the non-receptive response induced by capsaicin was significantly reduced by an intra-plantar injection of Lavender and Linalool. Oral administration or inhalation of lavender essential oil significantly reduced chemical and thermal pain without central adverse effects in adult mice.

The exposure to Lavender effectively improved the induced deficit of spatial memory due to the dysfunction of the cholinergic system (substance, drug or poison that acts by stimulating or producing effects equivalent to the actions of the parasympathetic nervous system, is also known as a neurotransmitter) therefore, its effects are similar to those produced by acetylcholine (neurotransmitter characteristic in animals). The administration of the Lavender in the 'animal model' of Alzheimer's disease can reverse the spatial learning deficits.



Repeated application of Lavender in mice showed a faster onset of sleep with increased duration. The anticonvulsant effect of Lavender worked against attacks through chemical convulsions induced in male mice. Lavender inhibited the onset, shortened duration and decreased intensity of the seizures.

It is reported that the anticonvulsant effects are created when Lavender is combined with other drugs. Inhalation of Lavender is also positively observed in inhibition induced by other chemical components, especially mice with seizures. Linalool, one of the main components of Lavender oil, has been shown to inhibit convulsions induced by other chemical components in different animal models.

The neuroprotective effect of Lavender oil on brain injuries in mice was investigated. An aqueous extract of Lavender has been shown to decrease the neurotoxicity induced by glutamate in rat pups with farming granular cells of the cerebellum. Lavender oil significantly decreased neurological problems, strokes, and neuronal damage in mice.

Several studies were conducted to clarify the actions of the Lavender in neuronal tissues. Lavender inhibits chemical components that are induced by inflammatory reactions, and are related with the cells associated to the expression of other components. Linalool was shown to inhibit the release of acetylcholine and alters a function related to the neuromuscular junction.

These findings indicate that several objectives relevant to the treatment of Alzheimer's disease could be found in Lavender. The neuroprotective effect of Lavender oil is suggested to be used for brain damage, and must be attributed to its antioxidant effects. The evaluation of the effects of Lavender oil in motor activity and its relationship with dopaminergic neurotransmission showed a significantly increased receptor activity of dopamine D in the olfactory bulbs of rats (Dopaminergic Neurotransmission is a term used to describe those substances or activities that increase the activity related to dopamine in the brain).



Lavender oil is also believed to serve the modulate neurotransmission and improve the inhibitory tone of the nervous system. This essential oil also serves as an analgesic, anxiolytic, antidepressant and anticonvulsant effects.

It has been shown that Lavender oil inhibits the sympathetic nerves that innervate the white and brown adipose tissue and adrenal gland, and also excites the parasympathetic gastric nerve. The smell of Lavender oil, especially its component linalool, can affect the autonomic nerves. The smell inhibits the production of heat (energy), increases appetite, and as a result, body weight in rats. Lavender can also inhibit the sympathetic nerve activity. The Hypothalamic neurons are also involved in certain responses to the Lavender oil (which are the most important region of the brain for the coordination of essential behaviors, linked to the maintenance of the species)

Part 1 of 3

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