Hiển thị các bài đăng có nhãn Infertility. Hiển thị tất cả bài đăng
Hiển thị các bài đăng có nhãn Infertility. Hiển thị tất cả bài đăng

Thứ Ba, 11 tháng 4, 2017

Smartphone Usage Linked to Male Infertility

By: Alexandria Addesso

The use of cellular phones, have become so common in our day-to-day lives that the inanimate objects almost become another appendage. Smart phones, the most commonly used type of cellular phones today rely on electromagnetic frequency (EMF) radiation to receive real time messaging. But could this form of frequencies be harmful when they are being transmitted all day?

Being that cell phones are portable, people tend to have them on their person all day. Men, more often than women, usually keep their cellular smart phones in their front pockets. Multiple recent studies have been conducted on whether keeping these cellular devices in such a close proximity to a man’s genitalia while transmitting EMF radiation could be harmful.



“Collectively, the research indicates that exposure to cell phone radiation may lead to decreases in sperm count, sperm motility and vitality, as well as increases in indicators of sperm damage such as higher levels of reactive oxygen species (chemically reactive molecules containing oxygen), oxidative stress, DNA damage and changes in sperm morphology ,” said The Environmental Working Group (EWG) after publishing a scientific literature review of 10 studies linking smartphone usage and male infertility.

Other studies even indicate specifically an 8 percent decrease in sperm motility and an approximate 9 percent decrease in sperm viability.
“Overall, these findings raise a number of related health policy and patient management issues that deserve our immediate attention. Specifically, we recommend that men of reproductive age who engage in high levels of mobile phone use do not keep their phones in receiving mode below waist level,” wrote researcher GN De Iuliis in the study Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro published in 2009.



Even though keeping your cell phone on a belt clip has long been seen as more safe, much data has shown that it is only slightly better than carrying it in your front pocket. If a man is trying to conceive a child it is best that he reduces his cell phone usage. Data on smartphone usage and female infertility is still widely unknown.

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Thứ Hai, 27 tháng 3, 2017

Researchers Find the Existence of another Immune System in Humans

The good news is that doctors can determine which antigens a patient’s cancer cells release. By targeting sequestered antigens – the ones unknown to the immune system – doctors could greatly increase vaccines’ chances of success. NeuroscienceNews.com image is credited to United States Department of Health and Human Services and is for illustrative purposes only.

A groundbreaking new study reveals an unexpected interaction between men’s testes and the immune system. Additionally, the findings could help explain the development of certain autoimmune disorders and why some cancer vaccines are ineffective.

Unexpected connection likely sabotaging vaccines designed to treat cancer.
The University of Virginia, School of Medicine, has again shown that a part of the body thought to be disconnected from the immune system actually interacts with it, and that discovery helps explain cases of male infertility, certain autoimmune diseases and even the failure of cancer vaccines.

Scientists developing such vaccines may need to reconsider their work in light of the new findings or risk unintentionally sabotaging their own efforts. UVA’s Kenneth Tung, MD, said that many vaccines likely are failing simply because researchers are picking the wrong targets – targets that aren’t actually foreign to the immune system and thus won’t provoke the desired immune responses.

Overturning Orthodoxy
Tung, of UVA’s Beirne B. Carter Center for Immunology Research, and a team of collaborators have discovered an unexpected interaction between men’s testes and the immune system. While science textbooks insist the testes are barricaded from the immune system by an impenetrable wall of cells, the researchers have determined there’s actually a very small door in that wall, a door that appears to open in only one direction.



The team discovered that the testes release some, but not all, of the antigens – substances that can spur an immune response – that are created during the production of sperm. Because the testes release these antigens naturally, the immune system ignores them. That’s a normal, healthy response, but it also may explain why cancer vaccines are failing. Cancer vaccines target antigens, so if vaccine developers rely on antigens that are ignored by the immune system, the vaccine won’t work.

“In essence, we believe the testes antigens can be divided into those which are sequestered [behind the barrier] and those that are not,” Tung said. “Antigens which are not sequestered would not be very good cancer vaccine candidates.”

The good news is that doctors can determine which antigens a patient’s cancer cells release. By targeting sequestered antigens – the ones unknown to the immune system – doctors could greatly increase vaccines’ chances of success.



Treating Infertility
The finding also may prove important for couples seeking to have children. Up to 12 percent of men who suffer from infertility have an autoimmune response to their own reproductive cells. That means their immune systems are attacking their sperm, essentially. Tung and his collaborators shed light on what may be happening, showing that a particular step during the creation of sperm is responsible for determining whether the sperm antigens will spark an immune response. Cells called “regulatory T cells” then help control the immune system’s response to the non-sequestered antigens. In men who are infertile because of an autoimmune disorder, something is going wrong with the process, leading the immune system to attack when it shouldn’t. With that knowledge, doctors may be able to develop new treatments for the autoimmune disorders and the resulting infertility.

Rethinking the Immune System
The discovery of the unknown immune interaction comes less than two years after UVA’s Jonathan Kipnis and Antoine Louveau rewrote textbooks when they discovered that the brain has a direct connection to the immune system, a connection long thought not to exist. That discovery could have profound effects in the quest to defeat diseases ranging from Alzheimer’s to multiple sclerosis.
Source: University of Virginia Health System.

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